What is the optimal dose of CBD, and is there a dose too high to be dangerous? Let’s dive into it.
Cannabidiol (CBD), for its many benefits, is considered to be a safe and side-effect molecule, with health potentials of enormous potential, all without any psychoactive effect or evidence to cause abusive use or dangerous overdose.
Following the “explosion” of the substance around the world, recent preliminary studies show that in very high doses it’s not necessarily more effective, and over time it may also damage the liver, similar to other drugs.
What is the correct dose of CBD?
Research has already found that the CBD efficacy curve for different labels is a ‘bell’ curve – meaning that starting from a certain dose, an increase in dose will no longer result in an increase in efficiency, but rather a decrease in efficacy.
In other words, the best dose of CBD is not the highest – but rather a medium or average dose.
The CBD efficiency curve is a “bell curve” – a higher dose is not necessarily more effective
Other studies suggest that the ‘bell curve’ is only a problem when it comes to CBD alone, in its pure forms(isolate), such as GW’s new drug, Epidiolex, recently officially recognized by the FDA as a drug treatment for seizures and epilepsy treatment.
According to these studies when it comes to CBD which is given with other cannabinoids and terpenes present in the cannabis plant, such as full-spectrum or broad spectrum, or when it is a CBD-rich cannabis strain(THC dominant), this problem disappears and treatment efficiency may increase as the dose increases.
How to Calculate the Correct Dose of CBD?
It’s difficult to determine universal doses of CBD that are right for each person because the dose needed varies significantly depending on the purpose of the treatment, the severity of the symptoms, and to some extent the body composition, it may even go further to our DNA. As for now, the best method for finding the right dose of CBD is to start at a low dose of 5-10 mg, and gradually increase if necessary until the desired effect is achieved.
Calculating the dosage of CBD in the product can be a little complicated in itself, as some products indicate the total amount of CBD in the product in milligrams (mg), and others indicate it as a percentage or ratio.
Most people will probably prefer to avoid calculations and complications and to know simply what the right number of CBD drops to take rather than mgs. For that, you can use our simple calculator that calculates your recommended dosage simply by entering your weight, and then the type of tincture you have. The calculator uses the average of 1–6MG of CBD for every 10 pounds of body weight – please take that into account when using it.
Is there such a thing as too much CBD?
Is there a danger of consuming too high doses of CBD? A study from the University of Arkansas published this year in the ‘Molecules’ magazine and got viral after it was also released in June in Forbes, tried to test how much CBD is needed to cause liver damage in mice. The doses given to mice in the study were extremely high – some of them receiving 2,400 mg for every pound of body weight in less than 24 hours. For other mice, the dose was divided over several days, and the liver injury appeared within days in those who received over 615 mg/kg daily.
However, as mentioned above, these are exceptionally high doses. For comparison, the maximum daily dose of CBD approved for human use by the FDA is only 20 mg/kg. The researchers argued that in order to convert the “human” dose to a parallel dose in mice, it should be doubled by more than 30 times in this case, but it is unclear how accurate or proper this conversion has been and has been widely criticized by researchers in the field.
But, even in the clinical trials of the drug ‘Epidiolex’, the first FDA-approved CBD drug, some subjects experienced an increase in liver enzyme levels, and this warning also appears in the side effects of the drug. The FDA protocol of the clinical trials at Epidylex states that “a clear increase in the levels of transaminases was observed in subjects receiving cannabidiol.” Transaminases are enzymes whose levels are tested in liver function tests, and their increase may indicate a liver problem.
According to the protocol, this side effect caused a “special interest” from the FDA, which demanded from the epidemic manufacturer, GW Pharmaceuticals, “to address the issue of liver safety through the opinion of an external liver disease expert.”The data from the clinical trials were also analyzed by the FDA’s Gastroenterology and epidemiology departments, which ultimately determined that the drug was safe to use at the recommended doses.
However, the concern for liver damage in long-term use at particularly high doses is a topic that is still being investigated so that, like many other drugs, the recommendation for those who take very high doses of CBD daily (over 15 mg for every kg of body weight) is to consult with the doctor and undergo a liver function test (simple blood test) once in a while to make sure everything is working properly.
Stay natural, stay healthy
Note: Original article by Cannabis Magazine Israel, this article was edited and translated for informational purposes